DYSPORT® 300u

DYSPORT® 300u – About and Key Features

DYSPORT® 300u (abobotulinumtoxinA) is a botulinum toxin type A product designed for intramuscular injection. It acts as a neuromuscular blocking agent by inhibiting acetylcholine release at the neuromuscular junction, leading to temporary muscle relaxation. Approved by the FDA in 2009, DYSPORT® is widely used for both medical and aesthetic treatments.

Key Features:

Indications: Treats cervical dystonia, upper limb spasticity in adults, lower limb spasticity in pediatric patients (2+ years), and glabellar lines in adults (<65 years).
Onset of Action: Effects appear within 1 week after injection.
Duration: Clinical results last approximately 12 to 16 weeks.
Dosage Strengths: Available in 300-unit and 500-unit lyophilized vials.
Mechanism: Blocks nerve signals to muscles, causing temporary relaxation.
Storage: Must be stored between 2°C and 8°C and used within 24 hours after reconstitution.
DYSPORT® 300u – Packaging and Ingredients
DYSPORT® 300u is supplied in a single-use, sterile vial as a white, lyophilized powder that must be reconstituted before injection.

Packaging Details:

Vial Size: Contains 300 units of abobotulinumtoxinA.
Formulation: Lyophilized powder for intramuscular injection.
Reconstitution Requirement: Must be diluted with preservative-free 0.9% sodium chloride solution before use.
Storage Conditions: Must be kept at 2°C to 8°C (36°F to 46°F) and protected from light.

Ingredients:

Active Ingredient: AbobotulinumtoxinA (botulinum toxin type A).
Inactive Ingredients: Human serum albumin (125 mcg) and lactose (2.5 mg).
Allergen Warning: May contain trace amounts of cow’s milk protein.

DYSPORT® 300u – Indications
DYSPORT® 300u is used for multiple therapeutic and aesthetic indications. However, specific contraindications and precautions must be observed.

Indications:

Cervical Dystonia: Reduces muscle stiffness and abnormal head positions.
Upper Limb Spasticity (Adults): Relieves excessive muscle tightness in arms.
Lower Limb Spasticity (Pediatrics, 2+ years): Treats muscle spasticity in children.
Glabellar Lines: Temporarily improves moderate to severe frown lines between the eyebrows.

Contraindications:

Allergy to botulinum toxin or formulation components.
Infection at the injection site.
Patients with neuromuscular disorders (e.g., myasthenia gravis).

Side Effects:

Common: Muscle weakness, headache, dry mouth, and injection site reactions.
Serious (Rare): Breathing difficulties, dysphagia, and generalized muscle weakness.
DYSPORT® 300u – Administration Technique and Storage
Proper administration of DYSPORT® 300u is crucial for efficacy and safety. It should only be injected by trained healthcare professionals.

Administration Technique:

Injection Route: Intramuscular (IM) injection only.
Reconstitution:
300-unit vial: Reconstitute with 0.6 mL of preservative-free 0.9% sodium chloride solution.
Final concentration: 50 units per 0.1 mL.
Injection Sites: Varies by indication; should be administered into targeted muscles.
Dosage:
Cervical Dystonia: Initial 500-unit dose divided across affected muscles.
Glabellar Lines: 50 units total, distributed into 5 equal 10-unit injections.
Upper Limb Spasticity: Based on severity; doses range from 500 to 1000 units.
Lower Limb Spasticity (Pediatrics): 10-15 units/kg per limb, with a max dose of 1000 units.
Injection Interval: No more frequent than every 12 weeks.
Storage Guidelines:
Before Reconstitution: Store vials at 2°C to 8°C (36°F to 46°F).
After Reconstitution: Must be used within 24 hours and kept refrigerated.
Do Not Freeze: Freezing compromises potency.
Light Protection: Store in original packaging to prevent degradation.
DYSPORT® 300u provides effective treatment for neuromuscular conditions and aesthetic concerns. Proper usage, dosage, and storage ensure its safety and efficacy.