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Weight Loss: Promotes significant fat loss and appetite suppression.
Metabolic Health: Improves insulin sensitivity and glucose control.
Obesity Research: Studied for its triple action in obesity management.
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Most Common Side Effects
- Gastrointestinal (GI) issues are the most frequent, often occurring during the first few weeks or following a dose increase:
- Nausea: Reported by up to 43-60% of participants on high doses in phase 2 trials.
- Diarrhea: Affects approximately 15-20% of users.
- Vomiting: Experienced by roughly 19-21% of those on the highest 12 mg dose.
- Constipation: Reported in about 16% of cases.
- Abdominal Pain: General discomfort or bloating is common as digestion slows.
Other Notable Effects - Heart Rate Increase: Trials showed a dose-dependent rise in resting heart rate, typically 5-10 beats per minute, which often peaks around week 24 and then declines.
- Skin Sensations: About 7% of participants reported “skin sensitivity” or tingling (dysesthesia), especially to heat or pressure.
- Fatigue & Headaches: Often linked to rapid weight loss and reduced calorie intake.
Typical Dosage & Administration
Administration: Subcutaneous injection.
Dosage:
- Typical doses range from 1 mg to 5 mg per week.
- Often administered once weekly, with gradual dose escalation.
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